Molecular features of malignant gastric tumors

Gastric cancer is one of the most widespread cancers and makes a significant contribution to global mortality rate from malignant neoplasms. The late onset clinical symptoms main reason why disease often diagnosed at an advanced stage, this limits available therapeutic approaches. Despite fact, that extensive studies have been carried out identify mechanisms markers development progression disease, their results are currently not fully included in practice. As consequence, only marginal improvement long-term survival has achieved patient prognosis remains poor. Understanding molecular genetic features gastric tumors can provide insight into pathogenesis, help new biomarkers for diagnosis, targets. In recent decades, advances high throughput sequencing technologies improved understanding aspects cancer. This review considers level changes, including information on tumor suppressor genes, oncogenes, cell cycle apoptosis regulators, adhesion molecules, loss heterozygosity, micro-satellite instability epigenetic aberrations (change methylation modification histones). also devoted pathogenesis – changes signaling pathways involved development; classification sporadic hereditary considered. characteristics GC presented levels confirms heterogeneous. These data be used both develop test potential targeted